eHealth is the use of information and communication technologies to support health and healthcare. It is also a school of thought about connectivity, social participation, and networked innovation. Policy makers, health care professionals, patients, insurers, researchers, and citizens alike, believe that eHealth will contribute to the solution of today's health issues and to the innovation of health care systems. In this book, health specialists - from the Center for eHealth Research and Disease Management at the University of Twente, along with the Dutch government's National Institute for Public Health and the Environment (RIVM) - explain what needs to be done to increase the impact and uptake of eHealth interventions. They do so by examining a range of hot topics, such as human-centered design, business modeling, persuasive technology, and the current trends at the intersection of health, social science, and technology. These topics converge in a holistic approach to the development and design of successful eHealth technologies.