Jason Bourne's old friend and covert brother-in-arms, Colonel Boris Karpov, is brutally murdered. The main suspect is Sara Yadin, a Mossad agent and Bourne's lover.

Jason Bourne is in Moscow to attend the wedding of his old friend and fellow spymaster General Boris Karpov. But amid the celebrations, the General has an important message to deliver to Bourne – 'a lifeline,' he says, 'for the end of the world'. Before Bourne can decipher this enigmatic warning, Karpov's wedding ends in chaos and bloodshed. Bourne discovers that the Russian has betrayed the Kremlin to forewarn him of the crippling disaster about to engulf the world. Bourne has just four days to discover the nature of the catastrophe and halt it. To get to the truth, Bourne must first track down an infamous and elusive arms dealer – a man both he and Karpov have been hunting for years. With the clock ticking, Bourne follows a labyrinthine path that weaves from the underbelly of Moscow to the pyramids of Egypt and the war-torn border between Syria and Turkey as he races to stop a world-threatening conspiracy in its tracks.