Tells the story of Yorick Brown, an unemployed slacker who discovers that he is the only male left in the world after a plague of unknown origin instantly kills every mammal with a "Y" chromosome. In this title, a Russian space from the International Space Station is returning to earth carrying three passengers: one woman and two men.

• Y: The Last Man is the gripping saga of Yorick Brown, an unemployed and unmotivated slacker who discovers that he is the only male left in the world after a plague of unknown origin instantly kills every mammal with a "Y" chromosome. Accompanied by his mischievous monkey and the mysterious Agent 355, York embarks on a transcontinental journey to find his girlfriend and discover why he is the last man on Earth.
• Now, the entire critically acclaimed Y: The Last Man saga written by Brian K. Vaughan, one of the writers of LOST, is collected into a new edition. In this second volume, a Russian space from the International Space Station is returning to earth carrying three passengers: one woman and two men. Could this be the end of Yorick's tenure as last living male? Plus, the group runs up against a roadblock in Arizona where the female remains of the Sons of Arizona militia have cut the interstate to keep out any vestiges of the U.S. government.
• Collects Y: The Last Man #11-23.