The book begins with my own health journey through mitochondrial fatigue and how I overcame it with the functional medicine approach to diagnosis and treatment. The first two chapters discuss the basic science of the mitochondria and their involvement in cell defense, energy production, aging, and cancer. The following chapters deals with the avoidance of chemicals, pesticides, and toxins that poison the mitochondria, food to nourish them, supplements, and hormetic lifestyle changes. The next chapter details the functional medicine approach to patient's symptoms using lab testing to arrive at the diagnosis and treatment. The book concludes with a summary of actionable items that the reader can do at home.

If you suffer from chronic fatigue, excess fat that you can't lose, brain fog, or any number of symptoms, the answer might just lie deep in your cell called mitochondria. They are responsible to make energy called ATP for the cell to function. If they sense danger to the cell and to themselves, they will shut down ATP production and go into cell defense mode, resulting in generalized dysfunction of the most active cells like the muscles and brain. You can now reverse this process using a validated method by the Mayo Clinic.

Dr. Chang has personally gone through a health journey of mitochondrial dysfunction and fatigue and by applying the methods in the book, he has fully recovered.