The Fundamental Wisdom of the Middle Way was written in the second century and is one of the most important works of Nagarjuna, the pioneering commentator on the Buddha's teachings on the Madhyamika or Middle Way view. The subtle analyses presented in this treatise were closely studied and commented upon by many realized masters from the Indo-Tibetan Buddhist tradition.

Using Nagarjuna's root text and the great modern master Ju Mipham's commentary as a framework, Khenpo Tsültrim Gyamtso explains the most important verse from each chapter in the text in a style that illuminates for modern students both the meaning of these profound teachings and how to put them into practice in a way that benefits both oneself and others.