After his wife, Helen, is abducted, Special Agent Pendergast furiously pursues the kidnappers, chasing them across the country and into Mexico. But then, things go terribly, tragically wrong; the kidnappers escape; and a shattered Pendergast retreats to his New York apartment and shuts out the world. But when a string of bizarre murders erupts across several Manhattan hotels, NYPD Lieutenant D'Agosta asks his friend Pendergast for help.