Though Sherlock Holmes and his sidekick Dr Watson solve what will become some of their extraordinary cases - the disappearance of the race horse Silver Blaze, the horrific circumstances of the Greek Interpreter and the curious mystery of the Musgrave Ritual among them - a criminal mastermind is plotting the downfall of the great detective.

'If I were assured of your eventual destruction I would, in the interests of the public, cheerfully accept my own.'

In The Memoirs of Sherlock Holmes, the consulting detective's notoriety as the arch-despoiler of the schemes concocted by the criminal underworld at last gets the better of him.

Though Holmes and his faithful sidekick Dr Watson solve what will become some of their most bizarre and extraordinary cases - the disappearance of the race horse Silver Blaze, the horrific circumstances of the Greek Interpreter and the curious mystery of the Musgrave Ritual among them - a criminal mastermind is plotting the downfall of the great detective.

Half-devil, half-genius, Professor Moriarty leads Holmes and Watson on a grisly cat-and-mouse chase through London and across Europe, culminating in a frightful struggle which will turn the legendary Reichenbach Falls into a water double-grave . . .